Many traditional critics tend to relate the supernatural images in Macbeth with the three Fates and thus ignored the dimension of psychological reality in the play. By applying Lacanian and Žižekian psychoanalysis in the interpretation of the supernatural images of the three witches in Macbeth, this paper concludes that the three witches are no more than the rhetoric of Macbeth’s inner desire, and their prophecy is the metonymy of Macbeth’s unconscious. Different witch imagery in different versions of Macbeth allow new interpretations of the play. Macbeth saw Lady Macbeth’s gaze on the three witches, and his desire was established through Lady Macbeth’s desire. Macbeth tried to respond to the emptiness of ‘the Other’ by filling up the emptiness of his inner desire but he lost himself in the pursuit of power. Lady Macbeth indulged herself in ‘surplus-enjoyment’ derived from Macbeth’s supreme royal power. However, when Lady Macbeth failed to satisfy her desire with surplus-enjoyment, she was doomed to lose her reason and perish. By describing the supernatural images and Macbeth’s uncanny dreams, William Shakespeare displays Macbeth’s and Lady Macbeth’s profound inner worlds, which reveal his concern about humanism to a greater extent.